Comments on: Cornies 2007: Protecting Group of the Year? Seriously? http://www.coronene.com/blog/?p=259 A chemistry blog about organic materials, nanocrap, life in the lab and kittens Fri, 10 Sep 2010 18:36:30 +0000 http://wordpress.org/?v=2.9 hourly 1 By: excimer http://www.coronene.com/blog/?p=259&cpage=1#comment-3306 excimer Mon, 14 Apr 2008 20:14:39 +0000 http://www.coronene.com/blog/?p=259#comment-3306 The Hiyama protocol looks nice- I hadn't seen that paper before. I can see a few reasons not to use it, such as prepping the organosilane and then protection (when you can just buy boronic acids) and if your stuff is really, really greasy, that group won't help much in purification. Might be a nice way to make sequential oligoarenes from one building block, but not so much if you have to make several different ones, like burke and suginome did. The Hiyama protocol looks nice- I hadn’t seen that paper before. I can see a few reasons not to use it, such as prepping the organosilane and then protection (when you can just buy boronic acids) and if your stuff is really, really greasy, that group won’t help much in purification. Might be a nice way to make sequential oligoarenes from one building block, but not so much if you have to make several different ones, like burke and suginome did.

]]> By: MYama http://www.coronene.com/blog/?p=259&cpage=1#comment-3305 MYama Mon, 14 Apr 2008 18:21:39 +0000 http://www.coronene.com/blog/?p=259#comment-3305 how about Hiyama coupling? see J. Am. Chem. Soc.. 2007, 129, 11694-11695. DOI: 10.1021/ja074728s and phenol-triflate strategy? see Chem. Lett. 2007, 36, 1302-1303. DOI: 10.1246/cl.2007.1302 how about Hiyama coupling?
see J. Am. Chem. Soc.. 2007, 129, 11694-11695. DOI: 10.1021/ja074728s
and phenol-triflate strategy?
see Chem. Lett. 2007, 36, 1302-1303. DOI: 10.1246/cl.2007.1302

]]> By: milkshake http://www.coronene.com/blog/?p=259&cpage=1#comment-2495 milkshake Tue, 08 Jan 2008 23:53:44 +0000 http://www.coronene.com/blog/?p=259#comment-2495 Slavic language are not-so-concise. They are rich on nuances and have absolutely horrific and irregular grammar. You have to learn 14 versions of each noun - they have affixes that change depending on the prepositions. The changes are irregular and depend also on the gender of the noun (each noun is he, she or it, completely unpredictably). You have to memorize it. On the up side there is only one past, one present and one future tense. All verbs tenses are irregular - plus there are 8 different forms of endings of the verb which signify who causes the action (5 in singular - me, you, he, she, it and 3 in plural mode - we, you, they) which are also pretty irregular and change with the tense also. I forgot to mention each verb comes at least in two similar (but grammatically differing) versions - one describes action that occured only once whereas the other one is for a continuous or repeated action. Oh, and there are few hard-to-pronounced sounds and letters that dont have a counterpart in other languages. Slavic language are not-so-concise. They are rich on nuances and have absolutely horrific and irregular grammar. You have to learn 14 versions of each noun – they have affixes that change depending on the prepositions. The changes are irregular and depend also on the gender of the noun (each noun is he, she or it, completely unpredictably). You have to memorize it.

On the up side there is only one past, one present and one future tense. All verbs tenses are irregular – plus there are 8 different forms of endings of the verb which signify who causes the action (5 in singular – me, you, he, she, it and 3 in plural mode – we, you, they) which are also pretty irregular and change with the tense also. I forgot to mention each verb comes at least in two similar (but grammatically differing) versions – one describes action that occured only once whereas the other one is for a continuous or repeated action. Oh, and there are few hard-to-pronounced sounds and letters that dont have a counterpart in other languages.

]]> By: Ψ*Ψ http://www.coronene.com/blog/?p=259&cpage=1#comment-2494 Ψ*Ψ Tue, 08 Jan 2008 21:59:53 +0000 http://www.coronene.com/blog/?p=259#comment-2494 It's a pretty language, but one I'll probably never learn. I always did kinda want to be able to read Dostoevsky in his original language, though. It’s a pretty language, but one I’ll probably never learn. I always did kinda want to be able to read Dostoevsky in his original language, though.

]]> By: Uncle Al http://www.coronene.com/blog/?p=259&cpage=1#comment-2493 Uncle Al Tue, 08 Jan 2008 17:44:42 +0000 http://www.coronene.com/blog/?p=259#comment-2493 Do you want oligoarenes? You can't handle oligoarenes! Oligo-1,4-phenylene yourself into a forced planar conjugation frenzy! 10,10-dibromo-9,9-bianthracene plus xs. benzyne into alpha,omega-dibromobitrypticene. Cook it up (fond memories of Tenderbutton) with molten dispersed sodium or free radical whatever to oligomerize. Monobromobitrypticene to control molecular weight distribution by capping. Now... FeCl3/MeNO2 to oxidately couple abutted rings with hydrogen extrusion, http://www.mazepath.com/uncleal/bitrypt2a.png condensed dimer, dimerized http://www.mazepath.com/uncleal/bitrypt2b.png condensed tetramer; alpha,omega H-termination Congrats on WIRED! Any route to grant funding advantage is a route to grant funding. Do you want oligoarenes? You can’t handle oligoarenes! Oligo-1,4-phenylene yourself into a forced planar conjugation frenzy!

10,10-dibromo-9,9-bianthracene plus xs. benzyne into alpha,omega-dibromobitrypticene. Cook it up (fond memories of Tenderbutton) with molten dispersed sodium or free radical whatever to oligomerize. Monobromobitrypticene to control molecular weight distribution by capping. Now… FeCl3/MeNO2 to oxidately couple abutted rings with hydrogen extrusion,

http://www.mazepath.com/uncleal/bitrypt2a.png
condensed dimer, dimerized
http://www.mazepath.com/uncleal/bitrypt2b.png
condensed tetramer; alpha,omega H-termination

Congrats on WIRED! Any route to grant funding advantage is a route to grant funding.

]]> By: Dave Eaton http://www.coronene.com/blog/?p=259&cpage=1#comment-2492 Dave Eaton Tue, 08 Jan 2008 14:37:28 +0000 http://www.coronene.com/blog/?p=259#comment-2492 I had several semesters of Russian. I can <i>barely</i> read it, and couldn't speak a lick even when I was in the classes. Part of that was just never studying stuff outside science and math, but I always though Russian was a pretty language to hear spoken. I've never tried to read anything scientific in Russian. I've read a bunch of translations of Russian mathematicians and physicists. It makes me wish I hadn't been such a slacker. Nah, not really. I had several semesters of Russian. I can barely read it, and couldn’t speak a lick even when I was in the classes. Part of that was just never studying stuff outside science and math, but I always though Russian was a pretty language to hear spoken. I’ve never tried to read anything scientific in Russian.

I’ve read a bunch of translations of Russian mathematicians and physicists. It makes me wish I hadn’t been such a slacker. Nah, not really.

]]> By: Russ http://www.coronene.com/blog/?p=259&cpage=1#comment-2491 Russ Tue, 08 Jan 2008 14:35:20 +0000 http://www.coronene.com/blog/?p=259#comment-2491 Solid indium is not actually that solid - indium is a rather soft malleable metal. But it's low melting point of 158 degrees C makes it a good candidate for home-made trophies I suppose. I used to work in an indium refinery as a Summer job during undergrad. I didn't know there was a global shortage - I wonder if I still have any "mementos" from those days... Solid indium is not actually that solid – indium is a rather soft malleable metal. But it’s low melting point of 158 degrees C makes it a good candidate for home-made trophies I suppose. I used to work in an indium refinery as a Summer job during undergrad. I didn’t know there was a global shortage – I wonder if I still have any “mementos” from those days…

]]> By: Ψ*Ψ http://www.coronene.com/blog/?p=259&cpage=1#comment-2490 Ψ*Ψ Mon, 07 Jan 2008 23:17:31 +0000 http://www.coronene.com/blog/?p=259#comment-2490 This is why I dropped Russian after a week in high school. This is why I dropped Russian after a week in high school.

]]> By: milkshake http://www.coronene.com/blog/?p=259&cpage=1#comment-2489 milkshake Mon, 07 Jan 2008 18:20:22 +0000 http://www.coronene.com/blog/?p=259#comment-2489 Burke's a one callous guy. Sensitivity to protic basic media is a big deal in Suzuki actually - many protocols do contain water because it helps the reaction. Burke’s a one callous guy.

Sensitivity to protic basic media is a big deal in Suzuki actually – many protocols do contain water because it helps the reaction.

]]> By: excimer http://www.coronene.com/blog/?p=259&cpage=1#comment-2488 excimer Mon, 07 Jan 2008 16:39:37 +0000 http://www.coronene.com/blog/?p=259#comment-2488 Yeah. It would have been nice to see the sensitivity of the protecting group to other reactions. Burke's, at least, seems to be insensitive to everything but water. Yeah. It would have been nice to see the sensitivity of the protecting group to other reactions. Burke’s, at least, seems to be insensitive to everything but water.

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